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Maximal CNS depression may not occur until 15 minutes or more after IV administration for phenobarbital sodium.
Clinical studies of Nembutal have not included sufficient numbers of subjects aged 65 and over to determine whether elderly subjects respond differently from younger subjects. Other reported clinical experience has not identified differences in responses between the elderly and younger patients.
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Caution should be exercised when barbiturates are administered to patients with acute or chronic pain, because paradoxical excitement could be induced or important symptoms could be masked.
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Slow IV injection is essential, and patients should be carefully observed during administration. This requires that blood pressure, respiration, and cardiac function be maintained, vital signs be recorded, and equipment for resuscitation and artificial ventilation be available. The rate of IV injection should not exceed 50 mg/min for pentobarbital sodium. Buy Nembutal online
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Pentobarbital is not used widely Per mezzo di clinical medicine because of its poor safety profile, habituation, and lack of an antidote. All prescribing clinicians should be aware of the drug's toxicity and adverse event profile. Neurologists can use pentobarbital for refractory status epilepticus.
The clinical significance of these nonclinical findings is not known, and healthcare providers should balance the benefits of appropriate anesthesia Sopra neonates and young children who require procedures against the potential risks suggested by the nonclinical patronato (see “WARNINGS-Pediatric Neurotoxicity” and “PRECAUTIONS-Pregnancy And Pediatric Use”).
Inadvertent intra-arterial administration can cause local reactions varying Per mezzo di severity from transient pain to gangrene. Inadvertent extravascular injection may cause local tissue damage and result Per mezzo di necrosis.
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Durante extreme overdose, all electrical activity in the brain may cease, Per mezzo di which case a “flat” EEG normally equated with clinical death cannot be click here accepted.
Documented evidence of withdrawal exists Per mezzo di infants born to mothers who took barbiturates during pregnancy. Newborns should be closely monitored for seizures and hyperirritability, which may indicate a need for withdrawal treatment. Symptoms can be delayed for up to 2 weeks and require prompt treatment if indicated.[25]